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Nutra Pharma Announces Study Showing RPI-78 More Effective than Morphine in the Treatment of Moderate to Severe Pain
June 08, 2009

A ReceptoPharm study published in Toxicon, the official journal of the International Society on Toxinology, shows that their leading drug candidate, RPI-78, is more effective than morphine in the treatment of pain.

Nutra Pharma Corp., a biotechnology company that is developing treatments for Adrenomyeloneuropathy (AMN), HIV and Multiple Sclerosis (MS), has announced today that its wholly-owned drug discovery subsidiary, ReceptoPharm, has published the positive results of its recent pain study in Toxicon, the official journal of the International Society on Toxinology. The study, which examined ReceptoPharm’s leading drug candidate for the treatment of pain, RPI-78, showed that the pain reducing effects of RPI-78 lasted four-times as long as morphine and without the negative side effects associated with opioid-based pain relievers.

“The results from this study provide a significant step forward in the development of an effective and non-narcotic treatment for moderate to severe pain,” commented Dr. Paul Reid, CEO of ReceptoPharm. “With these results in hand, we believe that RPI-78 could become the first non opioid-based analgesic dedicated to treating Stage II and Stage III pain,” he added.

In the central nervous system, the thalamic parafascicular nucleus (Pf) is considered one of the important processing centers for pain. The ReceptoPharm study showed that RPI-78 had a dose-dependent inhibitory effect on the electrical activity of Pf neurons in male Wistar rats that persisted for at least 2 hours in comparison to the inhibitory effect of morphine, which persisted no longer than 30 minutes. On a molecular basis, RPI-78 was observed to be 4,000 times more potent than morphine. Additionally, the study observed increased serotonin levels in subjects treated with RPI-78, which may explain the improved attitude in those subjects.

“While many opioid-based drugs provide fast and temporary pain relief, the negative side effect profiles and addictive properties of these medicines make them extremely difficult to administer,” explained Rik J Deitsch, Chairman and CEO of Nutra Pharma. “Because RPI-78 is more effective than morphine and does not produce these negative side effects, we believe that this drug could become the therapy of choice among hospitals and physicians in the near future,” he concluded.

SEC Disclaimer

This press release contains forward-looking statements. The words or phrases "would be," "will allow," "intends to," "will likely result," "are expected to," "will continue," "is anticipated," "estimate," "project," or similar expressions are intended to identify "forward-looking statements." Actual results could differ materially from those projected in Nutra Pharma's ("the Company") business plan. The Company's business is subject to various risks, which are discussed in the Company's filings with the Securities and Exchange Commission ("SEC"). ReceptoPharm’s published clinical study using RPI-78 as a treatment for pain should not be construed as an indication in any way whatsoever of the value of the Company or its common stock. The Company's filings may be accessed at the SEC's Edgar system at Statements made herein are as of the date of this press release and should not be relied upon as of any subsequent date. The Company cautions readers not to place reliance on such statements. Unless otherwise required by applicable law, we do not undertake, and we specifically disclaim any obligation, to update any forward-looking statements to reflect occurrences, developments, unanticipated events or circumstances after the date of such statement.

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